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Journalism Honours. Mathematics Honours. For eligibility criteria, additional information and to submit your application, please see the UQ Student Enrichment and Employability Development website. Solvent extracts prepared from each isolate will be analysed by mass spectrometry and antibiotic assays, to detect new classes of natural product with promising antibiotic properties.

The successful scholars will gain skills spanning microbiology and chemistry, while working in a dedicated microbial biodiscovery research laboratory. More specifically they will gain experience in:. Scholars will also acquire skills in safe lab practice, and scientific data acquisition, analysis, archive and communication. This project is suitable for 3 rd — 4 th year students majoring in microbiology, and with knowledge of organic chemistry.

Innate Immune cells such as macrophages, express a cellular machinery, so called inflammasomes, that are activated in response to danger signals and injury and provide the first defence of the organism. The interactions between endothelial cells expressing adhesion molecules and macrophages are important for activation of the inflammasomes and are involved in pathophysiology of chronic inflammatory diseases. However, the mechanism of inflammasomes activation by adhesion molecules is not understood.

This project aims to delineate those inflammatory processes and to investigate the interactions between macrophages and adhesion molecules leading to chronic inflammation. The successful scholar will gain skills in primary cellular culture, basic immunology techniques such as ELISA and western blots and data analysis.

The candidate will write a report and give oral presentation at the end of their project. This project is open to applications from students with a background in biology, molecular biology, science, or pharmacology, with some experience in cellular culture and molecular biology. Preferably students in 3 rd year of their study. For all enquires please email h.

But uncontrolled inflammation drives diseases such as gout, diabetes, neurodegenerative disease, and cancer. The Inflammasome Lab is defining the molecular and cellular processes of inflammation. We seek to unravel the secrets of inflammasomes — protein complexes at the heart of inflammation and disease — to allow for new therapies to fight human diseases. Several projects are on offer and will be tailored to the interests of the successful applicants.

Suitable topics include elucidation of: 1 mechanisms underpinning inflammasome signalling and pyroptotic cell death; 2 protective functions of inflammasomes during infection; and 3 pathogenic functions of inflammasomes during diseases such as genetic auto-inflammatory diseases, chronic liver disease or neurodegenerative diseases.

Project techniques may include molecular biology e. Scholars will have an opportunity to generate publications from their research. Students may also be asked to produce a report or oral presentation at the end of their project and will be given detailed feedback on these to enhance their communication skills.

Preference will be given to candidates in their third year of studies. For project queries please contact k. Our recent research show that the liver is subject to daily size fluctuations controlled by the circadian clock and feeding rhythms. The project will consist in further description of these changes through the analysis of histological slices and electron-microscopy images to describe the impact of time of day and the circadian clock on liver organisation and morphology.

The scholar will gain knowledge in image and data analysis as well as mammalian circadian physiology. Atomic level structural studies of the Commander and Retromer protein complexe s. Using recombinant protein expression, you will help to produce and characterise one of two essential protein complexes.

Commander is a distantly related complex also involved in intracellular membrane trafficking of receptors including the amyloid precursor protein and lipoprotein receptors, and its mutation causes X-linked intellectual disability.

Using biophysical analysis, crystallisation screens and structure determination we are aiming to determine how these protein complexes are assembled at the molecular level. Techniques that you may learn include bacterial cell culturing, DNA purification and handling and cell transfection, protein purification and crystallisation for X-ray diffraction structure determination.

There may also be scope for performing protein structural analyses. This project is open to applications from 3 rd year students with a background and interest in biochemistry, cell biology or structural biology.

Some experience in lab work e. For all enquires please email b. While the identity of terminally differentiated cells was once considered to be static, Takahashi and Yamanaka showed that by forcing the expression of transcription factors TFs such as Oct4, Klf4, Sox2 and c-Myc somatic cells can be reprogrammed towards the pluripotent state.

These cells are called induced pluripotent stem iPS cells and the phenomenon demonstrates that development is not unidirectional. Akin to iPS cell generation other TF combinations have been uncovered that allow direct transdifferentiation of one cell type into another one, such as direct reprogramming of fibroblasts into functional neurons using Ascl1, Brn2, Myt1 Vierbuchen et al.

Both iPSC generation and trans-differentiation show that a small number of TFs can reset the entire epigenome. Understanding how the TF network is rearranged between two different cell states by reprogramming is essential to improve existing reprogramming strategies and to enable new kinds of controlled cell state transitions. The aim of the project is the testing of TFs identified by the host laboratory for their ability to generate endodermal cell types e. Scholars will deepen established and acquire new laboratory skills e.

Scholars will be asked to communicate their findings to the lab e. The project could form the basis for future projects in the host laboratory. This project is open to applicants with a background in biotechnology, molecular biology, or cell biology.

The ideal candidate has some experience with cell culture. For informal conversations before submission of applications please contact Dr Christian Nefzger c. On a cellular level, ageing appears to be a largely epigenetic phenomenon. To uncover transcription factors TFs and chromatin state changes that drive ageing in different cell types, we have generated a molecular atlas RNAseq, ATACseq comprised of dozens of mammalian cell types from both young and aged subjects.

By pinpointing and analysing age-related changes to the TF network the project will reveal if there are TFs or TF families that drive ageing across different cell types or if ageing is a largely cell type specific process.

The project will leverage bulk data and entail computational techniques related to quantification of TF activity levels.

Integrative network analyses between transcriptional and chromatin state data will also be performed. The project aims to improve our understanding about the ageing process to ultimately find new ways that make aged cells work more efficiently. The student will be well supervised and does not need to be directly familiar with the analysis procedures for this project, however the ideal candidate will be able to efficiently program in R or Python. Students placed overseas who want to conduct a project remotely are welcome too.

Scholars will gain experience in working with methods in the field of computational biology. The ideal candidate has some demonstrated background in bioinformatics and as such is comfortable writing code in languages such as R, Matlab, Perl, or Python.

Synthesising conjugate drugs to kill bad bugs: Combining antibiotics to fight antimicrobial resistance. The project explores an innovative approach to treat drug-resistant infections and fight antimicrobial resistance AMR.

The approach involves functionalising legacy antibiotics with synthetic handles to allow different antibiotics to be covalently linked together. Aim : To synthesis a set of azide functionalised antibiotics and subsequently generate a small library of antibiotic-antibiotic hybrids. Scholars will gain skills in synthetic chemistry and drug design. Visit our Science Study Planner for information about our available majors single, extended and dual and recommended study plans.

For answers to frequently asked questions, and information about programs, applications, fees and student life, visit UQ's Future Students website. Visit our Study pages to find out which disciplines you can study at the undergraduate level.

See the range of scholarships and prizes available to undergraduates. Studying overseas can give your career a competitive edge. Global experiences , the University's student exchange program, allows you to study overseas for up to one year on exchange while gaining credit towards your UQ degree.